Synthesis of Polycyclic Indolines by Utilizing a Reduction/Cyclization Cascade Reaction

Synthesis of Enantioenriched Indolines by a Conjugate Addition/Asymmetric Protonation/Aza-Prins Cascade Reaction.

A conjugate addition/asymmetric protonation/aza-Prins cascade reaction has been developed for the enantioselective synthesis of fused polycyclic indolines. A catalyst system generated from ZrCl4 and 3,3'-dibromo-BINOL enables the synthesis of a range of polycyclic indolines in good yields and with high enantioselectivity. A key finding is the use of TMSCl and 2,6-dibromophenol as a stoichiometr...

Rapid access to polycyclic indolines related to the stephacidin alkaloids using a radical cascade.

A new and very rapid access to indoline intermediates useful for the synthesis of alkaloids related to the stephacidins has been established using a radical cascade process initiated from a sulphur-substituted diketopiperazine.

The asymmetric synthesis of polycyclic 3-spirooxindole alkaloids via the cascade reaction of 2-isocyanoethylindoles.

A highly enantioselective dearomative cascade reaction between 2-isocyanoethylindoles and 3-alkenyl-oxindoles was realized using a chiral N,N'-dioxide-Mg(II) complex catalyst. This reaction provides a straightforward access to polycyclic 3-spirooxindoles bearing cyclopenta[b]indole units with four contiguous stereocenters in excellent yields and moderate to good stereoselectivities via a Michae...

Total Synthesis of (+)-Linoxepin by Utilizing the Catellani Reaction**

Stereoselective synthesis of tetracyclic indolines via gold-catalyzed cascade cyclization reactions.

A reliable synthetic route to fused polycyclic indolines is documented by the development of a stereoselective gold catalyzed cascade cyclization of indole propargylic alcohols.